Investigation of the threshold for allergic reactivity to chromium

@article{Basketter2001InvestigationOT,
  title={Investigation of the threshold for allergic reactivity to chromium},
  author={David A Basketter and Liran Horev and Dany Slodovnik and Sharon Merimes and Akiva Trattner and Arieh Ingber},
  journal={Contact Dermatitis},
  year={2001},
  volume={44}
}
Allergy to chromium is relatively common, often in association with exposure to cement or in leather manufacture. However, in certain locations, there appears to be a relatively large cohort of chromium‐sensitive individuals whose allergy cannot be explained by these common sources. In particular, this group include Israeli housewives with persistent hand eczema and concomitant patch test positivity to chromium. The causation of their allergy has been linked with relatively high levels of… 
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References

SHOWING 1-10 OF 29 REFERENCES
Nickel, cobalt and chromium in consumer products: a role in allergic contact dermatitis?
TLDR
The analytical data demonstrate that consumer products are a relatively minor source of contact with nickel, cobalt or chromium, and it is necessary to focus on decreasing the high exposure to these transition metals from other sources rather than on possible trace amounts found in consumer products.
Follow-up study of patients with contact dermatitis caused by chromates, nickel, and cobalt.
TLDR
The patch test results from 1,000 patients tested with the ICDRG standard series are analyzed for positive reactions to potassium dichromate, nickel sulphate, and cobalt chloride and the relationship between these metals and hand and foot eczema is evaluated.
An arm immersion model of compromised skin
TLDR
Skin damage consequent upon arm immersion in sodium dodecyl sulphate (SDS) greatly enhanced reactivity to nickel on the forearm, with the dorsal aspect reacting most both in number of reactions at each concentration and in the minimal eliciting concentration.
Repeated exposures to cobalt or chromate on the hands of patients with hand eczema and contact allergy to that metal
TLDR
Standardization of chemical methods of quantification of skin exposure to allergens, combined with experimental exposure studies in patients with specific contact allergy, will increase the possibility of providing evidence‐based medicine in the area of allergic contact dermatitis in the future.
Chromium allergy in consecutive patients in a country where ferrous sulfate has been added to cement since 1981
TLDR
The aim of the study was to analyse a material of consecutive chromate‐sensitive patients in an urban tertiary referral centre with respect to primary cause of sensitization, in a geographical area where the risk of chromate exposure from cement had been reduced.
Prognosis of occupational chromate dermatitis
TLDR
In view of the potential chronicity of chromate dermatitis and its associated social and occupational impairment, the addition of ferrous sulphate‐while mixing bagged cement at the work site is recommended, which targets the workers at greatest risk of becoming sensitized.
Influence of detergent washing powders on minimal eliciting patch test concentrations of nickel and chromium
TLDR
EDTA significantly reduced the number and severity of patch test reactions to nickel sulphate but not those to potassium dichromate or trivalent chromium, and the minimum level of each metal required to provoke a patch test reaction was considerably greater than that found in fabric washing powder solutions.
Detergents and bleaches are sources of chromium contact dermatitis in Israel
TLDR
Almost 90% of the detergents and bleaches examined contained chromium levels higher than 1 ppm, and it is concluded that these consumer products may be the cause of the high incidence of chromium sensitivity in Israel.
Addition of ferrous sulfate to cement and risk of chromium dermatitis among construction workers
TLDR
Regardless of some potential confounders, the addition of ferrous sulfate to cement during the production process may have reduced the number of cases of allergic contact dermatitis among construction and concrete element prefabrication workers.
Eau de Javel and prevention of chromate allergy in France
TLDR
The results indicate that the almost complete removal of chromate in most brands of French eaux de Javel is a good example of prevention in the field of contact dermato‐allergology.
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