Investigation of the subtypes of a 1-adrenoceptor mediating contractions of rat vas deferens

@inproceedings{Honner1999InvestigationOT,
  title={Investigation of the subtypes of a 1-adrenoceptor mediating contractions of rat vas deferens},
  author={Valerie Honner and James Docherty},
  year={1999}
}
1 The subtypes of a1-adrenoceptor mediating contractions of rat vas deferens to endogenous and exogenous noradrenaline and to the exogenous agonists methoxamine, phenylephrine and A61603 have been examined. 2 The e€ects of antagonists on the shape of concentration-response curves, both tonic and phasic, to the four agonists were analysed. Prazosin produced parallel shifts in all cases. Particularly for RS 17053 against noradrenaline, there was some evidence for a resistant component of the… CONTINUE READING