Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils

@article{Wanikiat1997InvestigationOT,
  title={Investigation of the role of nitric oxide and cyclic GMP in both the activation and inhibition of human neutrophils},
  author={P. Wanikiat and D. Woodward and R. Armstrong},
  journal={British Journal of Pharmacology},
  year={1997},
  volume={122}
}
1 The aim of this study was to establish the role of nitric oxide (NO) and cyclic GMP in chemotaxis and superoxide anion generation (SAG) by human neutrophils, by use of selective inhibitors of NO and cyclic GMP pathways. In addition, inhibition of neutrophil chemotaxis by NO releasing compounds and increases in neutrophil nitrate/nitrite and cyclic GMP levels were examined. The ultimate aim of this work was to resolve the paradox that NO both activates and inhibits human neutrophils. 2 A role… Expand
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This study was designed to investigate the effects of the nitric oxide (NO) donors sodium nitroprusside (SNP), 3‐morpholinosydnonimine (SIN‐1) and S‐nitroso‐N‐acetylpenicillamine (SNAP) onExpand
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TLDR
It is demonstrated that human eosinophils present a nitric oxide-cyclic GMP pathway that is involved in the in vitro locomotion of this cell type. Expand
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TLDR
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