Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.

@article{Wong2004InvestigationOT,
  title={Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.},
  author={Florence S Wong and Li Wen and Michelle C. W. Tang and Murugappan Ramanathan and Irene P Visintin and Joanne Daugherty and Lynn G. Hannum and Charles A. Janeway and Mark J. Shlomchik},
  journal={Diabetes},
  year={2004},
  volume={53 10},
  pages={2581-7}
}
B-cells are important in the development of type 1 diabetes, but their role is not completely defined. Although B-cells produce autoantibodies, these are not thought to be pathogenic; however, their antigen-presenting function is postulated to be critical. To examine the relative importance of these functions of B-cells, we have generated nonobese diabetic (NOD) B-cell-deficient mice that express a transgene encoding a mutant heavy chain immunoglobulin transgene on the cell surface but cannot… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Identification of the THE ROLE OF B-CELLS IN TYPE 1 DIABETES 2586 DIABETES

  • CJ Hawkes, C Wasmeier, MR Christie, JC Hutton
  • VOL. 53,
  • 2004

Similar Papers

Loading similar papers…