Investigation of the release behavior of DEHP from infusion sets by paclitaxel-loaded polymeric micelles.

  title={Investigation of the release behavior of DEHP from infusion sets by paclitaxel-loaded polymeric micelles.},
  author={Sung Bae Kim and Hye Jeong Yoon and Jang Won Lee and Jaewon Yu and E Peter Park and Sang-Cheol Chi},
  journal={International journal of pharmaceutics},
  volume={293 1-2},
The current clinical formulation of paclitaxel (Taxol) contains 1:1 blend of Cremophor EL (polyethoxylated castor oil) and dehydrated ethanol. Cremophor EL and dehydrated ethanol are well known to leach di-(2-ethylhexyl) phthalate (DEHP) from polyvinyl chloride (PVC) infusion bags and PVC administration sets. DEHP is a possible hepatotoxin, carcinogen, teratogen and mutagen. Long-term exposure to DEHP may cause health risks. As an alternative formulation for paclitaxel, paclitaxel-loaded… CONTINUE READING


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