Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.

@article{Kosaka2005InvestigationOT,
  title={Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.},
  author={Tetsuya Minamitsuru-gun Kosaka and Masahiro Yamaguchi and Takashi Motomura and Kazuhiko Mizuno},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2005},
  volume={359 1-2},
  pages={
          156-62
        }
}
BACKGROUND It is known that serum paraoxonase activity decreases in patients with atherosclerotic diseases such as type 2 diabetes mellitus. Paraoxonase hydrolyzes homocysteine thiolactone, which is thought to be an endogenous substrate. The relationship between the status of atherosclerosis and homocysteine thiolactonase activity in patients with type 2 diabetes mellitus was investigated. METHOD Serum homocysteine thiolactonase activities in 207 patients with type 2 diabetes mellitus were… CONTINUE READING
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