Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.

Abstract

Elucidation of the rate-determining process in the overall hepatic elimination of drugs is critical for predicting their intrinsic hepatic clearance and the impact of variation of sequestration clearance on their systemic concentration. The present study investigated the rate-determining process in the overall hepatic elimination of the HMG-CoA reductase… (More)
DOI: 10.1124/dmd.109.030254

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@article{Watanabe2010InvestigationOT, title={Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.}, author={Takao Watanabe and Hiroyuki Kusuhara and Kazuya Maeda and Hiroshi Kanamaru and Yoshikazu Saito and Zhuohan Hu and Yuichi Sugiyama}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2010}, volume={38 2}, pages={215-22} }