Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein.

@article{Lawrence1992InvestigationOT,
  title={Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein.},
  author={Richard A. Lawrence and R. L. Jones},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 4},
  pages={817-24}
}
1. Prostaglandin E2 (PGE2) relaxes circular smooth muscle of the rabbit isolated jugular vein at very low concentrations (mean pIC50 against histamine-induced contraction = 9.34). This effect is not blocked by the EP1-receptor antagonist, AH 6809 (2 microM). 2. From a group of prostaglandin E analogues examined, 16,16-dimethyl PGE2, misoprostol, 11-deoxy PGE2-1-alcohol and 11-deoxy PGE1 were highly potent relaxant agents, whereas 17-phenyl-omega-trinor PGE2, MB 28767 and butaprost had low… CONTINUE READING
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