Investigation of the pattern of diversity of hepatitis C virus in relation to times of transmission

@article{Simmonds1997InvestigationOT,
  title={Investigation of the pattern of diversity of hepatitis C virus in relation to times of transmission},
  author={Peter Simmonds and D. B. Smith},
  journal={Journal of Viral Hepatitis},
  year={1997},
  volume={4}
}
Summary. The rate of sequence change of HCV in vivo was used to date the spread of HCV genotype 1b in European, USA and Japanese populations. Silent substitution rates of 0.0011 and 0.0017 substitutions per site per year were observed in the NS5 and E1 regions by sequence comparisons from a cohort of individuals infected from a common source of infection 17 years previously. Mean silent substitution frequencies of 0.169 and 0.224 in NS5 and E1, respectively, were observed amongst type 1b… 
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The differences in the main prevalent subtype between the three target groups suggest diversity of HCV prevalence in different populations.
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