Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38.

@article{Amin2014InvestigationOT,
  title={Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38.},
  author={Faisal Mohammad Amin and Anders Hougaard and Henrik Winther Schytz and Mohammad Sohail Asghar and Elisabet Lundholm and Arushma I Parvaiz and Patrick J. H. de Koning and Malene Rohr Andersen and Henrik B. W. Larsson and Jan Fahrenkrug and Jes Olesen and Messoud Ashina},
  journal={Brain : a journal of neurology},
  year={2014},
  volume={137 Pt 3},
  pages={779-94}
}
Pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide are structurally and functionally closely related but show differences in migraine-inducing properties. Mechanisms responsible for the difference in migraine induction are unknown. Here, for the first time, we present a head-to-head comparison study of the immediate and long-lasting observations of the migraine-inducing, arterial, physiological and biochemical responses comparing PACAP38 and… CONTINUE READING
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