Investigation of the oxytocin receptor expression in human breast cancer tissue using newly established monoclonal antibodies.

@article{Ito1996InvestigationOT,
  title={Investigation of the oxytocin receptor expression in human breast cancer tissue using newly established monoclonal antibodies.},
  author={Yoshimasa Ito and Tetsuro Kobayashi and Tomoatsu Kimura and Nariaki Matsuura and Eijiro Wakasugi and Takashi Takeda and Takashi Shimano and Yuri Kubota and T Nobunaga and Yoshinori Makino and Chihiro Azuma and Fumitaka Saji and Masayo Monden},
  journal={Endocrinology},
  year={1996},
  volume={137 2},
  pages={773-9}
}
The expression of the oxytocin (OT) receptor (OTR) in breast cancer was studied using newly established anti-OTR monoclonal antibodies. Immunoblotting indicated that the antibody 2F8 recognized a 70K OTR in the pregnant myometrium and breast cancer tissue. Among 57 breast cancer patients, we detected OTR immunoreactivity in 52 (91.2%) by immunohistochemistry using 2F8. Using another monoclonal antibody for different receptor domains, 1-2, the staining profile was identical in all positive… CONTINUE READING

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