Investigation of the opioid system in absence seizures with positron emission tomography.

@article{Bartenstein1993InvestigationOT,
  title={Investigation of the opioid system in absence seizures with positron emission tomography.},
  author={Peter Bartenstein and John S. Duncan and M C Prevett and Vincent J. Cunningham and David R. Fish and A. K. Jones and Sajinder K. Luthra and Guy V Sawle and David J. Brooks},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={1993},
  volume={56 12},
  pages={1295-302}
}
The neuroanatomical and pathophysiological basis of primary generalised absences is uncertain. Administration of endogenous opioids has been shown to result in absence-like seizures in animal models. Positron emission tomography scans were performed in eight patients with primary generalised epilepsy and eight control subjects. Regional cerebral blood flow was measured interictally with C15O2, after which a 90 minute dynamic study with the opioid-receptor ligand 11C-diprenorphine was performed… CONTINUE READING