Investigation of the morphology of intermediate filaments adsorbed to different solid supports.

@article{Mcke2005InvestigationOT,
  title={Investigation of the morphology of intermediate filaments adsorbed to different solid supports.},
  author={Norbert M{\"u}cke and Robert Kirmse and Tatjana Wedig and Jean François Leterrier and Laurent Kreplak},
  journal={Journal of structural biology},
  year={2005},
  volume={150 3},
  pages={268-76}
}
Morphologically, glutaraldehyde-fixed and -dried intermediate filaments (IFs) appear flexible, and with a width of 8-12 nm when observed by electron microscopy. Sometimes, the filaments are even unraveled on the carbon-coated grid and reveal a protofilamentous architecture. In this study, we have used atomic force microscopy to further investigate the morphology of IFs in a more physiological environment. First, we have imaged hydrated glutaraldehyde-fixed IFs adsorbed to a graphite support. In… CONTINUE READING

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