Investigation of the mechanisms of progesterone protection following oxygen–glucose deprivation in organotypic hippocampal slice cultures

@article{Radley2012InvestigationOT,
  title={Investigation of the mechanisms of progesterone protection following oxygen–glucose deprivation in organotypic hippocampal slice cultures},
  author={Elizabeth Radley and Asha Akram and B. Grubb and C. Gibson},
  journal={Neuroscience Letters},
  year={2012},
  volume={506},
  pages={131-135}
}
  • Elizabeth Radley, Asha Akram, +1 author C. Gibson
  • Published 2012
  • Biology, Medicine
  • Neuroscience Letters
  • This study aimed to test the hypothesis that progesterone is neuroprotective against oxygen-glucose deprivation (OGD) through its conversion to the active metabolite allopregnanolone (AlloP) and the potentiation of GABA(A) receptors. Organotypic hippocampal cultures were exposed to 2h of OGD and the resulting cell death was quantified 24h later using combined propidium iodide and Hoechst immunostaining. Initially, we confirmed, that both progesterone and AlloP were protective in terms of… CONTINUE READING
    15 Citations
    Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices
    • 41
    Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.
    • 23
    • PDF

    References

    SHOWING 1-10 OF 30 REFERENCES
    Progesterone protects against lipid peroxidation following traumatic brain injury in rats.
    • 287
    Progesterone Enhances Functional Recovery after Middle Cerebral Artery Occlusion in Male Mice
    • C. Gibson, S. Murphy
    • Medicine
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 2004
    • 178