Investigation of the mechanisms of improved oral bioavailability of bergenin using bergenin-phospholipid complex.

@article{Guan2014InvestigationOT,
  title={Investigation of the mechanisms of improved oral bioavailability of bergenin using bergenin-phospholipid complex.},
  author={Shan Guan and X. W. Qin and Zhou Zhou and Qiang Zhang and Yuan Huang},
  journal={Drug development and industrial pharmacy},
  year={2014},
  volume={40 2},
  pages={163-71}
}
AIM The purpose of this study was to investigate the detailed mechanisms of oral absorption enhancement of bergenin (BN) using BN-phospholipid complex (BPC). METHODS Multiple models such as ex vivo everted rat gut sac model and in vitro Caco-2 cell model were used. Meanwhile, the effect of chitosan on the enhancement of the permeability of BPC was evaluated. RESULTS The limited absorption of BN was significantly improved in both ex vivo everted rat gut sac model and in vitro Caco-2 cell… CONTINUE READING