[Investigation of the intramolecular cyclization of the thiophene substituted cyclohexane skeleton gamma-oxocarboxylic acid and synthesis of some N-heteroaryl isoindole derivatives].

Abstract

From thiophene and cis-hexahydrophthalic anhydride the corresponding gamma-oxocarboxylic acid was obtained by the Friedel-Crafts reaction, which resulted in new heterocycles with acetic anhydride, Lawesson reagent or urea by intramolecular cyclization. Saturated N-heteroaryl isoindoles were prepared directly by the fusion reaction of heteroaromatic amines with the oxocarboxylic acid.

Cite this paper

@article{Csende2011InvestigationOT, title={[Investigation of the intramolecular cyclization of the thiophene substituted cyclohexane skeleton gamma-oxocarboxylic acid and synthesis of some N-heteroaryl isoindole derivatives].}, author={Ferenc Csende}, journal={Acta pharmaceutica Hungarica}, year={2011}, volume={81 2}, pages={59-62} }