Investigation of the interactions of enteric and hydrophilic polymers to enhance dissolution of griseofulvin following hot melt extrusion processing.

@article{Bennett2015InvestigationOT,
  title={Investigation of the interactions of enteric and hydrophilic polymers to enhance dissolution of griseofulvin following hot melt extrusion processing.},
  author={Ryan C. Bennett and Justin M Keen and Yunxia Vivian Bi and Stuart Porter and Thomas D{\"u}rig and James W. McGinity},
  journal={The Journal of pharmacy and pharmacology},
  year={2015},
  volume={67 7},
  pages={918-38}
}
OBJECTIVES This study focuses on the application of hot melt extrusion (HME) to produce solid dispersions containing griseofulvin (GF) and investigates the in-vitro dissolution performance of HME powders and resulting tablet compositions containing HME-processed dispersions. METHODS Binary, ternary and quaternary dispersions containing GF, enteric polymer (Eudragit L100-55 or AQOAT-LF) and/or vinyl pyrrolidone-based polymer (Plasdone K-12 povidone or S-630 copovidone) were processed by HME… CONTINUE READING