Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans.

@article{Matsushima2008InvestigationOT,
  title={Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans.},
  author={Soichiro Matsushima and Kazuya Maeda and Naoki Ishiguro and Takashi Igarashi and Yuichi Sugiyama},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2008},
  volume={36 4},
  pages={
          663-9
        }
}
Fexofenadine (FEX), an H(1)-receptor antagonist, is eliminated from the liver mainly in an unchanged form. Our previous study suggested that organic anion-transporting polypeptide (OATP) 1B3 contributes mainly to the hepatic uptake of FEX. On the other hand, a clinical report demonstrated that a T521C mutation of OATP1B1 increased its plasma area under the plasma concentration-time curve. Several compounds are reported to have a drug interaction with FEX, and some of this may be caused by the… CONTINUE READING

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