Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors

@article{Closse2004InvestigationOT,
  title={Investigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors},
  author={Annemarie Closse and Annelise Jaton},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={326},
  pages={291-293}
}
  • A. ClosseA. Jaton
  • Published 1 July 1984
  • Biology, Psychology, Medicine
  • Naunyn-Schmiedeberg's Archives of Pharmacology
SummaryInvestigation of the influence of lithium upon the down-regulation of serotonin2 receptors in rat frontal cortex induced by long-term treatment with dibenzepin, an antidepressant without appreciable affinity to serotonin2 receptors.Groups of rats were treated orally for four weeks with either dibenzepin, lithiumcarbonate, or dibenzepine + lithium carbonate. Serotonin2 receptors were labelled with the new selective ligand [3H]mesulergine. Chronic treatment with dibenzepin caused down… 
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