Investigation of the in Vitro Metabolism of the Analgesic Flupirtine

  title={Investigation of the in Vitro Metabolism of the Analgesic Flupirtine},
  author={Karen Methling and Przyemslaw Reszka and Michael Lalk and Oldřich Vrána and Eberhard Scheuch and Werner Siegmund and Bernd Terhaag and Patrick J. Bednarski},
  journal={Drug Metabolism and Disposition},
  pages={479 - 493}
The in vitro metabolism of flupirtine, ethyl-N-[2-amino-6-(4-fluorophenylmethyl-amino)pyridine-3-yl]carbamate, a centrally acting analgesic with muscle tone-reducing activity, was studied. Two flupirtine metabolites were already known: the N-acetylated analog D13223 and 4-fluorohippuric acid. The structure of flupirtine suggested that redox chemistry may play a role in metabolism, and cyclic voltammetry studies showed that the drug undergoes facile and irreversible redox reactions. Thus… 

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