Investigation of the importance of the N-terminal peptide bonds of substance P by synthetic pseudopeptide analogs.

Abstract

Synthetic Substance P analogs where each of the first five peptide bonds are replaced by the peptide bond surrogate Gly psi [CH2CH2]Gly are investigated as ligands to the Neurokinin 1 (NK1) receptor from rat cerebral cortex. The affinities of these analogs are then compared with the corresponding Gly-Gly analogs. With this model system replacement of the… (More)

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