Investigation of the human metabolism of antipyrine using coupled liquid chromatography and nuclear magnetic resonance spectroscopy of urine.

Abstract

The potential of coupled high-performance liquid chromatography-nuclear magnetic resonance spectroscopy for the detection and identification of drug metabolites has been investigated by direct analysis of human urine collected following administration of antipyrine. This approach provided a rapid method of characterizing the major human urinary metabolites… (More)

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@article{Wilson1993InvestigationOT, title={Investigation of the human metabolism of antipyrine using coupled liquid chromatography and nuclear magnetic resonance spectroscopy of urine.}, author={Coralie Wilson and Joseph Nicholson and M. Hofmann and M. Spraul and John C. Lindon}, journal={Journal of chromatography}, year={1993}, volume={617 2}, pages={324-8} }