Investigation of the association of the SLC11A1 gene with resistance/sensitivity of goats (Capra hircus) to paratuberculosis.

@article{Korou2010InvestigationOT,
  title={Investigation of the association of the SLC11A1 gene with resistance/sensitivity of goats (Capra hircus) to paratuberculosis.},
  author={L. Korou and E. Liandris and M. Gazouli and J. Ikonomopoulos},
  journal={Veterinary microbiology},
  year={2010},
  volume={144 3-4},
  pages={
          353-8
        }
}
SLC11A1 (solute carrier family 11 member A1) protein is located on the phagolysosome membrane of macrophages and participates in bacterial killing. Here we have extended our previous work on the investigation of the potential association of polymorphisms of the 3'untranslated region (UTR) of SLC11A1 gene with test-positivity of goats to Mycobacterium avium subsp. paratuberculosis (MAP). Blood, serum and faeces were collected from 223 adult goats, from nine goat farms from Greece with a long… Expand
Polymorphisms at the 3' untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats.
TLDR
Polymorphisms in regions A and B of the 3'UTR SLC11A1 gene were found statistically significant associated with protection to Brucella infection, and open a promising opportunity for limiting goat brucellosis through selective breeding of animals based on genetic markers associated with natural resistance to B. melitensis infection. Expand
Evaluation of the association of SLC11A1 gene polymorphism with incidence of paratuberculosis in goats
TLDR
The results suggest that caprine SLC11A1 gene has significant role in paratuberculosis resistance in goats and further studies might help in development of a PCR-based genotyping test for paratubculosis resistance and selection of superior animals for future goat breeding programmes. Expand
In vitro expression of the SLC11A1 gene in goat monocyte-derived macrophages challenged with Mycobacterium avium subsp paratuberculosis.
  • S. Taka, E. Liandris, +5 authors J. Ikonomopoulos
  • Biology, Medicine
  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2013
TLDR
The homozygous B7 genotype [B(GTn)7/7] was associated at a statistically significant level with increased expression of the SLC11A1 and IL-1α genes indicating increased in vitro responsiveness and therefore resistance of mononuclear derived macrophages to MAP infection. Expand
Functional analysis of 3'UTR polymorphisms in the caprine SLC11A1 gene and its association with the Mycobacterium avium subsp. paratuberculosis infection.
TLDR
The two polymorphic regions of the 3'UTR of the caprine SLC11A1 gene were recognized as regulators of its activity, at transcriptional and post-transcriptional level and the specific genotype was found to be more responsive to MAP exposure at a statistically significant level. Expand
Characterisation of exon 9 of solute carrier family 11 member A1 gene in Vechur cattle
TLDR
The results suggest that there exists a considerable genetic variation at SLC11A1 locus and further association studies may help in development of a PCR based genotyping assay to select cattle with better immunity to intracellular pathogens. Expand
Sequence characterization, structural analysis, SNP detection and expression profiling of SLC11A1 gene in Indian goats
TLDR
The study indicated the presence of four synonymous and three non-synonymous mutations in SLC11A1, which is essential for immunity and resistance to intracellular pathogens in native goats of Kerala. Expand
Genetic variability in the A microsatellite at SLC11A1 gene and possible implications with innate resistance against brucellosis in Algerian native goats
TLDR
The genetic variability of the A microsatellite at the 3' untranslated region (3' UTR) of SLC11A1 gene in Algerian native goat breeds as it was associated with Brucellosis genetic resistance in goat opens a promising opportunity to implement a genetic improvement program to reduce goat brucellosis spread. Expand
Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: a review.
TLDR
The current published evidence for a genetic association with paratuberculosis susceptibility, technological advances that have progressed the field and potential avenues for future research are reviewed. Expand
Variabilidad genÈtica en el microsatÈliteAdel extremo 3¥UTR del genSLC11A1 en un rebaÒo de cabras Criollas ( Capra hircus) Genetic variability in the microsatelliteAat region 3 UTR of theSLC11A1 gene in a herd of native goats ( Capra hircus)
The SLC11A1 gene encodes a cationic transporter located in the membrane of phagolysosome of macrophages, which has active participation in the suppression of bacterial infections and has twoExpand
Molecular analysis of solute carrier family 11 member a1 (Slc11a1) gene in ruminants and non-ruminants using computational method
TLDR
Detailed analysis of the Slc11a1 gene revealed that twenty five of the amino acid substitutions at the peptide binding region could be beneficial, while only one was harmful and the rest twenty were beneficial. Expand
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