Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus.

@article{McKnight2010InvestigationOT,
  title={Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus.},
  author={Amy-Jayne McKnight and Kerry A. Pettigrew and Christopher C. Patterson and Jill Kilner and Denise M. Sadlier and Alexander Peter Maxwell},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2010},
  volume={27 6},
  pages={624-30}
}
AIMS Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease. METHODS The BMP7 gene was screened, variants identified and… CONTINUE READING