• Corpus ID: 28749219

Investigation of the anti-inflammatory, antinociceptive effect of ellagic acid as measured by digital paw pressure via the Randall-Selitto meter in male Sprague-Dawley rats.

@article{Gainok2011InvestigationOT,
  title={Investigation of the anti-inflammatory, antinociceptive effect of ellagic acid as measured by digital paw pressure via the Randall-Selitto meter in male Sprague-Dawley rats.},
  author={Jeffrey Gainok and R. Gary Daniels and David Golembiowski and Patricia Kindred and L Post and Rob Strickland and Normalynn Garrett},
  journal={AANA journal},
  year={2011},
  volume={79 4 Suppl},
  pages={
          S28-34
        }
}
Ellagic acid (EA), a dietary supplement, is purported to have anti-inflammatory, antinociceptive properties via cyclooxygenase (COX) inhibition. We measured the antinociceptive efficacy of EA alone and in combination with a nonselective COX inhibitor and a selective COX-2 inhibitor. We assigned 54 male Sprague-Dawley rats to 1 of 6 groups to be given the following compounds: (1) vehicle, (2) ketorolac (nonselective COX inhibitor), (3) meloxicam (selective COX-2 inhibitor), (4) EA, (5) EA plus… 
Ellagic acid enhances the antinociceptive action of venlafaxine in mouse acetic acid-induced pain: An isobolographic analysis.
TLDR
The synergistic action of EA and VLF provides valuable tool referring to the management of visceral pain by producing synergistic interaction against writhing behaviors, as revealed by isobolographic analysis.
Ellagic acid enhances the antinociceptive action of carbamazepine in the acetic acid writhing test with mice
TLDR
Results suggest that a combination of carbamazepine and ellagic acid may be a new strategy for the management of neuropathic pain such as what occurs in trigeminal neuralgia, since the use of carbazepine is often limited by its adverse effects and by reduction of its analgesic effect through microsomal enzyme induction.
Antinociceptive and anti-inflammatory activities of a pomegranate (Punica granatum L.) extract rich in ellagitannins
TLDR
The present results reinforce the benefits of pomegranate (poly)phenolics in the treatment of pain as well as their anti-inflammatory properties.
Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain.
TLDR
JAK2 inhibitors may represent a novel class of non-narcotic drugs to treat inflammatory pain and attenuated ʎ-carrageenan-induced thermal hyperalgesia in a dose-dependent manner.
Ellagic acid enhances morphine analgesia and attenuates the development of morphine tolerance and dependence in mice.
TLDR
Results showed that ellagic acid has notable systemic antinociceptive activity for both tonic and phasic pain models and might be used in pain relief alone or in combination with opioid drugs because of enhancing morphine analgesia and preventing morphine-induced tolerance to analgesia, tolerance and dependence.
Anti-inflammatory and antinociceptive activities of the leaf methanol extract of Miconia minutiflora (Bonpl.) DC. and characterization of compounds by UPLC-DAD-QTOF-MS/MS
TLDR
The anti-inflammatory action mechanism of Mm-MeOH is associated with inhibition of proinflammatory cytokines TNF-α and IL-1β, whereas the antinociceptive actions involve peripheral and central mechanisms with participation of α2-adrenergic receptors.
Comparative Study of Anti-nociceptive Activity and Phenolic Content of the Ethanol Extracts of Piper nigrum and Piper longum Fruits
The research was carried out for investigation of anti-nociceptive properties, and phenolic compound determination by HPLC-DAD method of the ethanol extracts of P. nigrum of two varieties (black and
In Vivo Anti-Inflammatory and in Vitro Antioxidant Activities of Toona Ciliata Leaves Native to Bangladesh
TLDR
The study was performed to assess the anti-inflammatory, antioxidant activities and identify the polyphenols of Toona ciliata grown in Bangladesh and found total antioxidant capacity, total phenolic and flavonoid content were found to be 357.1 mg/g ascorbic acid, 239.2mg/g gallic Acid, and 98.36 mg/G quercetin equivalent.
The polyphenol ellagic acid exerts anti-inflammatory actions via disruption of store-operated calcium entry (SOCE) pathway activators and coupling mediators.
TLDR
By inhibiting SOCE mediated Ca2+ influx, EA decreased downstream activation of pro-inflammatory mediators and suggest a novel target for EA-mediated effects and provide insight into the mechanisms underlying EA- mediated anti-inflammatory effects.
In vivo, In vitro anti-arthritic studies of Ellagic acid from Kirganelia reticulata Baill and its molecular docking
TLDR
The isolated compound EA showed anti-arthritic activity which was found to be significant to that of the standard drugs and supports the traditional use of plant for rheumatism.
...
1
2
3
...

References

SHOWING 1-10 OF 35 REFERENCES
Evaluation of the anti-inflammatory effects of ellagic acid.
TLDR
The findings suggest that ellagic acid may be effective against inflammation, may have a prolonged onset and duration of action, and may interact with known cyclooxygenase inhibitors.
Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.
TLDR
These studies indicate that NSAID have a powerful effect upon spinal nociceptive processing evoked by the s.c.p.t. injection of formalin.
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
TLDR
Parecoxib, when administered parenterally, has potent antihyperalgesic, anti-inflammatory, antipyretic effects and has a better safety profile than with ketorolac, with sparing of cyclooxygenase-1 in the stomach in these animal models.
Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.
TLDR
It is suggested that continuous production of PGE2 by the COX-2 enzyme is a critical element in sustaining the hyperalgesic response at sites of tissue inflammation.
Involvement of peripheral prostaglandins in formalin-induced nociceptive behaviours in the orofacial area of rats
TLDR
Results suggest that PGs, particularly peripheral PGs are involved in nociceptive behaviour following formalin injection in the orofacial area, and nonsteroidal anti-inflammatory drugs had no effect on the phase-1 response of the formalin test.
Antinociceptive activity of alcoholic extract of Hemidesmus indicus R.Br. in mice.
The ethanolic extract of roots of Hemidesmus indicus R.Br. (family: Asclepiadaceae) was investigated for possible antinociceptive effect in mice. Three models were used to study the effects of
The thrombopenic effect of ellagic acid in the rat. Another model of platelet stimulation "in vivo".
TLDR
In immune platelet depleted rats, EA induced only the swelling of lymph nodes and of the spleen, and it is suggested that the pro-aggregating derivatives of arachidonic acid had a minor role in this stimulation.
Comparison of Ketorolac Tromethamine with Other Injectable Nonsteroidal Anti-Inflammatory Drugs for Pain-on-Injection and Muscle Damage in the Rat
TLDR
Overall, ketorolac was better tolerated in the assay than the other injectable NSAIDs, thereby suggesting the possibility of improved local tolerance on clinical use.
Anti‐inflammatory, analgesic and anti‐oedematous effects of Lafoensia pacari extract and ellagic acid
TLDR
Results demonstrate potential therapeutic effects of L. pacari extract and ellagic acid, providing new prospects for the development of drugs to treat pain, oedema and inflammation.
Distribution and metabolism of ellagic acid in the mouse following intraperitoneal administration.
  • R. Teel
  • Chemistry, Medicine
    Cancer letters
  • 1987
TLDR
Most of the radioactivity recovered from both bile and urine was associated with EA, and the two organs showing the highest amount of radioactivity were kidney and liver and the lowest was in brain.
...
1
2
3
4
...