Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls.

@article{Posthumus2009InvestigationOT,
  title={Investigation of the Sp1-binding site polymorphism within the COL1A1 gene in participants with Achilles tendon injuries and controls.},
  author={Michael Viljoen Wayne Posthumus and Alison V September and Martin Schwellnus and Malcolm Collins},
  journal={Journal of science and medicine in sport},
  year={2009},
  volume={12 1},
  pages={
          184-9
        }
}
Sequence variants within the type V collagen (COL5A1) and tenascin C (TNC) genes have to date been shown to be associated with chronic Achilles tendinopathies and/or spontaneous Achilles tendon ruptures. Type V collagen and tenascin C are quantitatively minor components of tendon, while type I collagen is the major structural component. There is increased expression of the COL1A1 gene, which encodes for the alpha1 chain of type I collagen, in the painful Achilles tendon. A functional Sp1… CONTINUE READING
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