Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium

@inproceedings{Thompson2011InvestigationOT,
  title={Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium},
  author={Chad M Thompson and Deborah M. Proctor and Laurie C. Haws and Charles D. H{\'e}bert and Sheila D. Grimes and Howard G. Shertzer and Anna K. Kopec and J. Gregory Hixon and Timothy R. Zacharewski and Mark A. Harris},
  booktitle={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2011}
}
Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice. To investigate the mode of action (MOA) underlying these tumors, a 90-day drinking water study was conducted using similar exposure conditions as in a previous cancer bioassay, as well as lower (heretofore unexamined) drinking water concentrations. Tissue samples were collected in mice exposed for 7 or 90 days and subjected to histopathological, biochemical… CONTINUE READING

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