Investigation of the Anti-Inflammatory Potential of Aloe vera Gel (97.5%) in the Ultraviolet Erythema Test

@article{Reuter2008InvestigationOT,
  title={Investigation of the Anti-Inflammatory Potential of Aloe vera Gel (97.5\%) in the Ultraviolet Erythema Test},
  author={Juliane Reuter and Andrea Jocher and Jacob Stump and Beatrice Grossjohann and Gerd Franke and C. M. Schempp},
  journal={Skin Pharmacology and Physiology},
  year={2008},
  volume={21},
  pages={106 - 110}
}
Background:Aloe vera is a natural product that is frequently used in soothing skin care products such as aftersun lotions. In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo. Methods: 40 volunteers with skin types II and III were included in the randomized, double-blind, placebo-controlled, phase III monocenter study. Test areas on the back were irradiated with the 1.5-fold minimal erythema dose of UVB… Expand
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Aloe vera has been traditionally used to treat various conditions, including psoriasis, sunburn or radiation-related dermatitis, mucositis, oesophagitis or lichen planus and has also found application in wound healing, treatment of burns, protection against skin damage caused by X-ray, intestinal problems, reduction of plaque and gingivitis and improving the immune system. Expand
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TLDR
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TLDR
The measured scores for all factors showed the superiority of Aloe vera gel compared to placebo in mitigating the apparent side-effects after phototherapy sessions, however, the mean of burning sensation intensity did not differ after two weeks, but did in the subsequent time points. Expand
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TLDR
The silicone plus herbal extract gel appears to be superior to A. vera gel in prevention of hypertrophic scars formation in patients with dermal burns. Expand
An Aloe Vera-Based Cosmeceutical Cream Delays and Mitigates Ionizing Radiation-Induced Dermatitis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: A Clinical Study
TLDR
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References

SHOWING 1-10 OF 31 REFERENCES
Anti-Inflammatory Effect of Hamamelis Lotion in a UVB Erythema Test
TLDR
Evidence is provided for an anti-inflammatory action of the aftersun lotion with 10% hamamelis and the usefulness of the UVB erythema test with multiple UV doses for the testing of nonsteroidal anti- inflammatory agents is supported. Expand
The UV Erythema Test as a Model to Investigate the Anti-Inflammatory Potency of Topical Preparations – Reevaluation and Optimization of the Method
TLDR
The UV erythema test seems to be suitable only for substances with corticosteroid-like effects, since in this test model the calcineurin inhibitor pimecrolimus was not effective and should be performed on the back with at least 40 subjects using the 1.5-fold MED. Expand
Anti-Inflammatory Efficacy of Topical Preparations with 10% Hamamelis Distillate in a UV Erythema Test
TLDR
It was possible to make an objective selection of the best hamamelis distillate for aftersun purposes and the hydrocortisone formulations were most effective in erythema suppression. Expand
Aloe vera leaf gel: a review update.
TLDR
Research since the 1986 review has largely upheld the therapeutic claims made in the earlier papers and indeed extended them into other areas and a common theme running though much recent research is the immunomodulatory properties of the gel polysaccharides, especially the acetylated mannans from Aloe vera, which are now a proprietary substance covered by many patents. Expand
Effect of drugs on the early and late phase UV erythema.
TLDR
The results reported suggest that the UVB response is biphasic with an early phase responsive to nonsteroid anti-inflammatory drugs and a late phase which is not responsive. Expand
The degrees of UVB-induced erythema and pigmentation correlate linearly and are reduced in a parallel manner by topical anti-inflammatory agents.
TLDR
It is concluded that the measurement of UVB-induced hyperpigmentation can be utilized for the assessment of topical anti-inflammatory agents, unless these have direct actions on the tyrosinase activity of melanocytes. Expand
Aloe vera: a systematic review of its clinical effectiveness.
  • B. Vogler, E. Ernst
  • Medicine
  • The British journal of general practice : the journal of the Royal College of General Practitioners
  • 1999
TLDR
Oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidaemia and topical application is not an effective preventative for radiation-induced injuries. Expand
An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera
  • M. Boudreau, F. Beland
  • Medicine
  • Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
  • 2006
TLDR
A review of the botany, physical and chemical properties, and biological activities of the Aloe vera plant finds that it contains multiple constituents with potential biological and toxicological activities, yet the active components elude definition. Expand
Antiinflammatory activity of extracts from Aloe vera gel.
TLDR
It is demonstrated that the extracts of Aloe vera gel have antiinflammatory activity and suggested its inhibitory action on the arachidonic acid pathway via cyclooxygenase. Expand
Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats.
TLDR
Aloe vera could exhibit the actions of both anti-inflammation and wound healing promotion when applied on a second degree burn wound. Expand
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