Investigation of the 5-HT receptor mediating relaxation in guinea-pig proximal colon.

Abstract

5-Hydroxytryptamine (5-HT) induced concentration-related relaxations (EC50 = 9.1 microM) of guinea-pig proximal colon pretreated with ketanserin (1 microM) and ondansetron (10 microM). This 5-HT-induced effect was neuronally mediated since it was blocked by tetrodotoxin (0.3 microM). 5-Carboxamidotryptamine was a full agonist and ten times more potent than… (More)

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