Investigation of spin-trapping artifacts formed by the Forrester-Hepburn mechanism.

Abstract

Free radical detection with ESR spin trapping relies on the specific addition of the radical to nitrone/nitroso compounds. It also has been proposed that spin traps can react in biological systems to give false-positive results. For nitrone spin traps, the reaction with nucleophiles, first described by Forrester and Hepburn, has been discussed as the most… (More)
DOI: 10.1016/j.freeradbiomed.2013.07.006

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