Investigation of some biologically relevant redox reactions using electrochemical mass spectrometry interfaced by desorption electrospray ionization.

@article{Lu2012InvestigationOS,
  title={Investigation of some biologically relevant redox reactions using electrochemical mass spectrometry interfaced by desorption electrospray ionization.},
  author={Mei Lu and Chloe Wolff and Weidong Cui and Hao Chen},
  journal={Analytical and bioanalytical chemistry},
  year={2012},
  volume={403 2},
  pages={355-65}
}
Recently we have shown that, as a versatile ionization technique, desorption electrospray ionization (DESI) can serve as a useful interface to combine electrochemistry (EC) with mass spectrometry (MS). In this study, the EC/DESI-MS method has been further applied to investigate some aqueous phase redox reactions of biological significance, including the reduction of peptide disulfide bonds and nitroaromatics as well as the oxidation of phenothiazines. It was found that knotted/enclosed… CONTINUE READING