Investigation of single-molecule kinetics mediated by weak hydrogen bonds within a biological nanopore.

@article{Asandei2011InvestigationOS,
  title={Investigation of single-molecule kinetics mediated by weak hydrogen bonds within a biological nanopore.},
  author={Alina Asandei and Aurelia Apetrei and Yoonkyung Park and Kyung-soo Hahm and Tudor Luchian},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2011},
  volume={27 1},
  pages={
          19-24
        }
}
The study of factors essential for protein-peptide interactions and protein pore-mediated peptide transport are of particular relevance in biology. Wild-type α-hemolysin was adopted as a "nanoreactor" in which perturbations of the current through a protein containing a lumen-residing, aryl-capped antimicrobial peptide were seen for the first time and studied at the single-molecule level. Energy and steric considerations hint that Met-aryl interactions between aromatic residues placed at a… CONTINUE READING

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