Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA

  title={Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA},
  author={Felix Hasler and Erich Studerus and Kerstin Lindner and Stephan Ludewig and F. X. Vollenweider},
  journal={Journal of Psychopharmacology},
  pages={923 - 935}
Serotonin (5-HT) release is the primary pharmacological mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) action in the primate brain. Dopamine release and direct stimulation of dopamine D2 and serotonin 5-HT2A receptors also contributes to the overall action of MDMA. The role of 5-HT1A receptors in the human psychopharmacology of MDMA, however, has not yet been elucidated. In order to reveal the consequences of manipulation at the 5-HT1A receptor system on cognitive and… 
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Neurochemical substrates of the rewarding effects of MDMA: implications for the development of pharmacotherapies to MDMA dependence
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Effects of Acute MDMA Intoxication on Mood and Impulsivity: Role of the 5-HT2 and 5-HT1 Receptors
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&agr;1-Adrenergic Receptors Contribute to the Acute Effects of 3,4-Methylenedioxymethamphetamine in Humans
The results indicate that &agr;1-adrenergic receptors contribute to the acute cardiostimulant and to a minor extent possibly also to the thermogenic and euphoric effects of MDMA in humans.
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MDMA administration was overall safe in physically and psychiatrically healthy subjects and in a medical setting, however, the risks of MDMA are likely higher in patients with cardiovascular disease and remain to be investigated in Patients with psychiatric disorders.
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3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions.
Evidence is summarized to suggest that the influence of 5-HT receptors on behavioral function is dependent upon the specific neurochemical environment evoked by a given drug, specifically discussed here with regard to the interaction between 5- HT and DA systems.
MDMA induced dopamine release in vivo: role of endogenous serotonin
It is concluded that 5-HT release after (+)-MDMA treatment partially contributes to (+-MDMA's effect on DA release in vivo, and the selective DA transport inhibitor GBR-12909 (1 μM), blocked (+)- MDMA’s effect onDA release.
Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine.
It is indicated that S-MDMA produces a characteristic form of locomotor hyperactivity in rats that depends upon activation of 5-HT1-like receptors, possibly of the 5- HT1B subtype.
Acute and long-term effects of MDMA on cerebral dopamine biochemistry and function
It is suggested more focus be made on the actions of MDMA on dopamine neurochemistry and function to provide a better understanding of the acute and long-term consequences of using this popular recreational drug.
Gender differences in the subjective effects of MDMA
The fact that equal doses of MDMA per kilogram body weight produce stronger responses in women compared to men is consistent with an increased susceptibility of women to the 5-HT-releasing effects of MDMA.
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
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