Investigation of racial variations in the metabolism of tramadol

  title={Investigation of racial variations in the metabolism of tramadol},
  author={D. S. Ogunleye},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
Metabolism of tramadol, 1-(m-methyoxyphenyl)-2-(dimethyllamminomethyl)-cyclohexan-1-ol, in man was investigated using urine of healthy male volunteers. The drug was administered orally and the urine was extracted and analysed by gas chromatography. Tramadol and two of its metabolites were detected in urine. The major metabolic pathways were O- and N… CONTINUE READING