Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis

@article{Mizukami2014InvestigationOP,
  title={Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis},
  author={Keijiro Mizukami and Akira Yabuki and Daiji Endoh and H. S. Chang and K W Lee and Masanari Nakayama and Kazuya Kushida and Moeko Kohyama and J. I. Lee and Osamu Yamato},
  journal={Veterinary Record},
  year={2014},
  volume={175},
  pages={174 - 174}
}
Collie eye anomaly (CEA) is an inherited canine ocular disorder causing regional choroidal hypoplasia and coloboma of the optic disk or adjacent areas, and is associated with a 7.8-kilo base pair (bp) deletion in the canine NHEJ1 gene (Parker and others 2007). A 4-bp deletion in the canine MDR1 / ABCB1 gene ( MDR1 gene defect) causes neurotoxicosis after administration of P-glycoprotein substrates such as ivermectin (Gramer and others 2011). These two mutations are common in collie-related and… 
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