Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis

  title={Investigation of parallel and simultaneous selection for collie eye anomaly and ivermectin toxicosis},
  author={Keijiro Mizukami and Akira Yabuki and Daiji Endoh and H. S. Chang and K W Lee and Masanari Nakayama and Kazuya Kushida and Moeko Kohyama and J. I. Lee and Osamu Yamato},
  journal={Veterinary Record},
  pages={174 - 174}
Collie eye anomaly (CEA) is an inherited canine ocular disorder causing regional choroidal hypoplasia and coloboma of the optic disk or adjacent areas, and is associated with a 7.8-kilo base pair (bp) deletion in the canine NHEJ1 gene (Parker and others 2007). A 4-bp deletion in the canine MDR1 / ABCB1 gene ( MDR1 gene defect) causes neurotoxicosis after administration of P-glycoprotein substrates such as ivermectin (Gramer and others 2011). These two mutations are common in collie-related and… 
4 Citations
What do European veterinary codes of conduct actually say and mean? A case study approach
This paper provides the first systematic investigation of veterinary CPCs, combining content and thematic analyses of five purposively selected European CPCs: Federation of Veterinarians of Europe (FVE), Denmark, Ireland, Portugal and the UK.
Understanding the primary care paradigm: an experiential learning focus of the early veterinary graduate
A lack of experience in general practice case types, and how to best operate in the resource-constrained environment in which they present, is the likely cause of this, suggesting that a greater focus on the primary care paradigm is needed within veterinary education.
Exploring how end-of-life management is taught to Australasian veterinary students. Part 1: technical euthanasia
Competency in euthanasia techniques is an important aspect of clinical practice and these findings can be used to inform curriculum reviews of veterinary training.


Collie eye anomaly in Hokkaido dogs: case study.
The data suggest that the Hokkaido breed is highly susceptible to CEA because of the known CEA-associated mutation much like the Collie-related breeds.
Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage.
It is concluded that all dogs carrying mdr1-1Delta are descendants of a dog that lived in Great Britain before the genetic isolation of breeds by registry (ca. 1873), whereas the breed distribution and frequency have applications in veterinary medicine and selective breeding.
Breed distribution of the nt230(del4) MDR1 mutation in dogs.
A Novel Rapid Genotyping Technique for Collie Eye Anomaly: SYBR Green–Based Real-Time Polymerase Chain Reaction Method Applicable to Blood and Saliva Specimens on Flinders Technology Associates Filter Paper
  • Hye-sook Chang, K. Mizukami, O. Yamato
  • Biology
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2010
SYBR Green–based real-time PCR combined with FTA cards is a rapid genotypes technique for CEA that can markedly shorten the overall time required for genotyping as well as simplify the sample preparation.
Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds.
This work establishes that the primary cea mutation arose as a single disease allele in a common ancestor of herding breeds as well as highlights the value of comparative population analysis for refining regions of linkage.
Rapid genotyping assays for the 4–base pair deletion of canine MDR1/ABCB1 gene and low frequency of the mutant allele in Border Collie dogs
  • K. Mizukami, Hye-sook Chang, O. Yamato
  • Biology
    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
  • 2012
P-glycoprotein, encoded by the MDR1 or ABCB1 gene, is an integral component of the blood–brain barrier as an efflux pump for xenobiotics crucial in limiting drug uptake into the central nervous
Phylogenetic studies of dogs with emphasis on Japanese and Asian breeds
  • Y. Tanabe
  • Biology
    Proceedings of the Japan Academy. Series B, Physical and biological sciences
  • 2007
Ethological studies have revealed a significant breed difference in behavioral traits among canine breeds with Japanese dogs, showing more aggressive dispositions than most of European dogs.
Rethinking dog domestication by integrating genetics, archeology, and biogeography
The results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation, suggesting that studies of modern breeds have yet to shed light on dog origins.
Relation between erythrocyte reduced glutathione and glutamate concentrations in Korean Jindo dogs with erythrocytes possessing hereditary high activity of Na-K-ATPase and a high concentration of potassium.
The results indicate that HK Jindo dogs have normal to very high levels of erythrocyte GSH, which might result from the varying quantity of Na-dependent glutamate influx in the ERYthrocytes.