Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System.

@article{Koziolek2015InvestigationOP,
  title={Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System.},
  author={Mirko Koziolek and Michael Grimm and Dieter Becker and Ventzeslav P. Iordanov and Hans Zou and Jeff Shimizu and Christoph Wanke and Grzegorz Garbacz and Werner Weitschies},
  journal={Journal of pharmaceutical sciences},
  year={2015},
  volume={104 9},
  pages={2855-63}
}
Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were investigated in two studies with each 10 healthy human subjects using the IntelliCap(®) system. This telemetric drug delivery device enabled the determination of gastric emptying time, small bowel transit time, and colon arrival time by significant pH and temperature changes. The study results revealed high variability of GI pH and transit times. The gastric transit of IntelliCap(®) was characterized by high… CONTINUE READING

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