Investigation of norovirus replication in a human cell line

  title={Investigation of norovirus replication in a human cell line},
  author={Kazuhiko Katayama and Grant S Hansman and Tomoichiro Oka and Satoko Ogawa and Naokazu Takeda},
  journal={Archives of Virology},
Noroviruses (NoVs) belong to the genus Norovirus and are members of the family Caliciviridae. NoVs are the dominant cause of outbreaks of gastroenteritis, but progress in understanding the molecular characteristics of NoV and its replication strategies have been hampered by the lack of a cell culture system or a practical animal model, except for murine NoVs. To elucidate the transcription and replication of the NoV genome, a complete genome of a human NoV genogroup II strain was cloned… CONTINUE READING


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