Investigation of non-enzymatic glycosylation of human serum albumin using ion trap-time of flight mass spectrometry.


Non-enzymatic glycosylation or glycation involves covalent attachment of reducing sugar residues to proteins without enzyme participation. Glycation of glucose to human serum albumin in vivo is related to diabetes and many other diseases. We present an approach using liquid chromatography coupled to an electrospray ionization source of a hybrid ion trap… (More)
DOI: 10.3390/molecules17088782

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