Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach.

@article{Mbius2013InvestigationOL,
  title={Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach.},
  author={Kristin M{\"o}bius and Karoline Nordsieck and Annelie Pichert and Sergey A. Samsonov and Lars Thomas and J{\"u}rgen Schiller and Stefan Kalkhof and Mar{\'i}a Teresa Pisabarro and Annette G Beck-Sickinger and Daniel Huster},
  journal={Glycobiology},
  year={2013},
  volume={23 11},
  pages={1260-9}
}
Although the interaction between interleukin-8 (IL-8) and glycosaminoglycans (GAGs) is crucial for the mediation of inflammatory effects, little is known about the site specificity of this interaction. Therefore, we studied complexes of IL-8 and heparin (HEP) as well as other GAGs in a multidisciplinary approach, involving site-directed mutagenesis, mass spectrometry, fluorescence and solution NMR spectroscopy as well as computer modeling. The interaction between GAG and IL-8 is largely driven… CONTINUE READING

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