Investigation of layer-by-layer assembly of polyelectrolytes on fully functional human red blood cells in suspension for attenuated immune response.

@article{Mansouri2011InvestigationOL,
  title={Investigation of layer-by-layer assembly of polyelectrolytes on fully functional human red blood cells in suspension for attenuated immune response.},
  author={Sania Mansouri and Yahye Merhi and Françoise M. Winnik and Maryam Tabrizian},
  journal={Biomacromolecules},
  year={2011},
  volume={12 3},
  pages={
          585-92
        }
}
  • Sania Mansouri, Yahye Merhi, +1 author Maryam Tabrizian
  • Published in Biomacromolecules 2011
  • Chemistry, Medicine
  • The encapsulation of live cells with polymeric coat-ings is a versatile approach to modulate or control the response cells to their environment. The layer-by-layer (LbL) self-assembly of nonimmunogenic polyelectrolytes is employed here to attenuate or suppress the binding of antibodies to live red blood cells (RBCs) and, consequently, decrease their inherent immunogenicity toward foreign RBCs. The optimized shell was composed of four bilayers of alginate (AL) and chitosan-graft… CONTINUE READING

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