Investigation of induced changes in interleukin 1beta mRNA expression by cultured human dendritic cells as an in vitro approach to skin sensitization testing.

@article{Pichowski2000InvestigationOI,
  title={Investigation of induced changes in interleukin 1beta mRNA expression by cultured human dendritic cells as an in vitro approach to skin sensitization testing.},
  author={Johanna S. Pichowski and Marie Cumberbatch and Dearman and David A Basketter and I A N Kimber},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2000},
  volume={14 4},
  pages={351-60}
}
It has been reported previously that in vitro treatment of human blood derived dendritic cells (DC) with contact allergens provokes the elevated expression of mRNA for interleukin (IL) 1beta, under conditions where similar treatment of cells with the non-sensitizing skin irritant sodium lauryl sulfate (SLS) did not alter IL-1beta mRNA levels (Reutter et al., 1997). The purpose of the present investigation was to evaluate further this phenomenon and to explore the potential utility of this… CONTINUE READING
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