Investigation of in vitro biocompatibility of novel pentablock copolymers for gene delivery.

@article{Agarwal2007InvestigationOI,
  title={Investigation of in vitro biocompatibility of novel pentablock copolymers for gene delivery.},
  author={Ankit Agarwal and Robert C. Unfer and S K Surya K Mallapragada},
  journal={Journal of biomedical materials research. Part A},
  year={2007},
  volume={81 1},
  pages={24-39}
}
Novel pentablock copolymers of poly(diethylaminoethylmethacrylate) (PDEAEM), poly(ethylene oxide) (PEO), and poly(propylene oxide) (PPO), (PDEAEM-b-PEO-b-PPO-b-PEO-b-PDEAEM), were synthesized as vectors for gene delivery, and were tested for their biocompatibility on SKOV3 (human ovarian carcinoma) and A431 (human epidermoid cancer) cell lines under different in vitro conditions using various assays to elucidate the mechanism of cell death. These copolymers form micelles in aqueous solutions… CONTINUE READING