Investigation of human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble/highly permeable drug (efavirenz).

@article{Gao2007InvestigationOH,
  title={Investigation of human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble/highly permeable drug (efavirenz).},
  author={Julia Z H Gao and M D Anower Hussain and Rajeshwar Motheram and David B. Gray and Irma H. Benedek and William D. Fiske and Walter J. Doll and Erik P. Sandefer and Richard C Page and George A. Digenis},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 11},
  pages={2970-7}
}
Human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble, highly permeable, micronized drug (efavirenz) was investigated. The tablets and capsule, prepared with samarium oxide and neutron activated to produce radioactive samarium-153, were evaluated for their in vivo disintegration and gastrointestinal (GI) transit in healthy subjects under fasted condition. Scintigraphic images were acquired to coincide with blood sampling times to… CONTINUE READING

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