Investigation of human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble/highly permeable drug (efavirenz).

@article{Gao2007InvestigationOH,
  title={Investigation of human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble/highly permeable drug (efavirenz).},
  author={Julia Z H Gao and M D Anower Hussain and Rajeshwar Motheram and David Alfred Gray and Irma Helene Benedek and William D. Fiske and Walter J. Doll and Erik P. Sandefer and Ronald C. Page and George A. Digenis},
  journal={Journal of pharmaceutical sciences},
  year={2007},
  volume={96 11},
  pages={
          2970-7
        }
}
Human pharmacoscintigraphic behavior of two tablets and a capsule formulation of a high dose, poorly water soluble, highly permeable, micronized drug (efavirenz) was investigated. The tablets and capsule, prepared with samarium oxide and neutron activated to produce radioactive samarium-153, were evaluated for their in vivo disintegration and gastrointestinal (GI) transit in healthy subjects under fasted condition. Scintigraphic images were acquired to coincide with blood sampling times to… CONTINUE READING
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Sex-by-formulation interaction assessed through a bioequivalence study of efavirenz tablets.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2016
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