Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK.

@article{Hinks2007InvestigationOG,
  title={Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK.},
  author={Anne Hinks and Stephen Eyre and Anne Barton and Wendy Thomson and Jane Worthington},
  journal={Annals of the rheumatic diseases},
  year={2007},
  volume={66 5},
  pages={683-6}
}
OBJECTIVE To investigate single-nucleotide polymorphisms (SNPs) across the PTPN22 gene region in a UK cohort of patients with rheumatoid arthritis (RA), to look for evidence of disease associations independent of the well-characterised R620W variant (rs2476601). METHODS 951 RA cases in the UK satisfying American Rheumatism Association (ARA) criteria and 448 population controls were genotyped for 11 SNPs across the PTPN22 gene region using the Sequenom MassArray MassEXTEND technology. Allele… CONTINUE READING

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