• Medicine
• Published in Industrial health 2011
• DOI:10.2486/indhealth.MS1218

Investigation of gene expression of MMP-2 and TIMP-2 mRNA in rat lung in inhaled nickel oxide and titanium dioxide nanoparticles.

@article{Morimoto2011InvestigationOG,
  title={Investigation of gene expression of MMP-2 and TIMP-2 mRNA in rat lung in inhaled nickel oxide and titanium dioxide nanoparticles.},
  author={Yasuo Morimoto and Takako Oyabu and Akira Ogami and Toshihiko Myojo and Etsushi Kuroda and Masami Hirohashi and Manabu Shimada and Wuled Lenggoro and Kikuo Okuyama and Isamu Tanaka},
  journal={Industrial health},
  year={2011},
  volume={49 3},
  pages={
          344-52
        }
}

• Yasuo Morimoto, Takako Oyabu, +7 authors Isamu Tanaka

In order to investigate whether or not dispersed nanoparticles have an effect of inflammation and fibrosis on animals, we developed a nanoparticle generation system and examined the gene expression of matrix metalloproteinase (MMP) and tissue inhibitor matrix proteinase (TIMP) in rat lung containing inhaled nickel oxide (NiO) or titanium dioxide (TiO(2)) nanoparticles. In both experiments, Wistar male rats were exposed to NiO or TiO(2) nanoparticles for 4 wk (6 h/day). The geometric mean… CONTINUE READING

View PDF

Save to Library

Create Alert

Cite