Investigation of gene expression of MMP-2 and TIMP-2 mRNA in rat lung in inhaled nickel oxide and titanium dioxide nanoparticles.

@article{Morimoto2011InvestigationOG,
  title={Investigation of gene expression of MMP-2 and TIMP-2 mRNA in rat lung in inhaled nickel oxide and titanium dioxide nanoparticles.},
  author={Yasuo Morimoto and Takako Oyabu and Akira Ogami and Toshihiko Myojo and Etsushi Kuroda and Masami Hirohashi and Manabu Shimada and Wuled Lenggoro and Kikuo Okuyama and Isamu Tanaka},
  journal={Industrial health},
  year={2011},
  volume={49 3},
  pages={
          344-52
        }
}
In order to investigate whether or not dispersed nanoparticles have an effect of inflammation and fibrosis on animals, we developed a nanoparticle generation system and examined the gene expression of matrix metalloproteinase (MMP) and tissue inhibitor matrix proteinase (TIMP) in rat lung containing inhaled nickel oxide (NiO) or titanium dioxide (TiO(2)) nanoparticles. In both experiments, Wistar male rats were exposed to NiO or TiO(2) nanoparticles for 4 wk (6 h/day). The geometric mean… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Nickel oxide nanoparticles induced pulmonary fibrosis via TGF-β1 activation in rats

X-R Chang, An Zhu, +10 authors Yifan Sun
  • Human & experimental toxicology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Inhalation of ZnO Nanoparticles: Splice Junction Expression and Alternative Splicing in Mice

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 18 REFERENCES