Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527.

@article{Schuh1988InvestigationOF,
  title={Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527.},
  author={Silke Schuh and Joan S. Brugge},
  journal={Molecular and cellular biology},
  year={1988},
  volume={8 6},
  pages={2465-71}
}
Phosphorylation at tyrosine 527 of the proto-oncogene product, pp60c-src, has been proposed to decrease the tyrosine kinase activity of the enzyme. We have investigated potential factors that might influence phosphorylation at this site by making mutant variants of the pp60c-src protein. By effectively eliminating the site of N-terminal myristylation, we demonstrated that stable membrane association is not necessary for tyrosine 527 phosphorylation. Furthermore, mutational elimination of the… CONTINUE READING
7 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…