Investigation of factor Xa inhibitors containing non-amidine S1 elements.

  title={Investigation of factor Xa inhibitors containing non-amidine S1 elements.},
  author={Jeffry B Franciskovich and John J. Masters and Jennifer M Tinsley and Trelia J. Craft and Larry L Froelich and Donetta S Gifford-Moore and Valentine J. Klimkowski and Jeffrey K. Smallwood and Gerald F. Smith and Tommy H Smith and Richard R Towner and Leonard C Weir and Michael R. Wiley},
  journal={Bioorganic & medicinal chemistry letters},
  volume={15 21},
Several non-amidino S1 derivatives of the 1,2-diaminobenzene-based scaffold (4) were synthesized and evaluated for their ability to bind to the active site and inhibit the human protease factor Xa. A subset of these compounds were also evaluated for their anticoagulant effects in human plasma as measured by prothrombin time (PT).