Investigation of estrogen status and increased stroke sensitivity on cerebral blood flow after a focal ischemic insult.

@article{Carswell2000InvestigationOE,
  title={Investigation of estrogen status and increased stroke sensitivity on cerebral blood flow after a focal ischemic insult.},
  author={Hilary V O Carswell and Niall H. Anderson and James J. Morton and J. Mcculloch and Anna F. Dominiczak and I Mhairi Macrae},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2000},
  volume={20 6},
  pages={
          931-6
        }
}
Recently the authors have shown that female stroke-prone spontaneously hypertensive rats (SHRSPs) in proestrus (high endogenous estrogen), sustain more than 20% smaller infarcts after middle cerebral artery occlusion (MCAO) compared with SHRSPs in metestrus (low endogenous estrogen). Because estrogen has vasodilator properties, the authors investigated whether the estrous state influences cerebral blood flow (CBF) after MCAO. CBF was measured 2.5 hours after a distal MCAO by [14C]iodo… CONTINUE READING

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