Investigation of endogenous neurotransmitters of guinea pig gallbladder using nicotinic agonist stimulation.

@article{Parkman1998InvestigationOE,
  title={Investigation of endogenous neurotransmitters of guinea pig gallbladder using nicotinic agonist stimulation.},
  author={Henry P. Parkman and Anthony P. Pagano and J. P. Ryan},
  journal={Digestive diseases and sciences},
  year={1998},
  volume={43 10},
  pages={2237-43}
}
Gallbladder motility is modulated by intrinsic nerves, the identities of which are not well established. The aim of this study was to determine the effect of nicotinic receptor stimulation of intrinsic nerves on gallbladder muscle contractility. Guinea pig gallbladder muscle strips were studied in vitro. Histamine 1 microM was used to increase baseline tone. The nicotinic receptor agonist, 1,1-dimethyl-4-phenylpiperazinium (DMPP), produced a biphasic response characterized by an initial… CONTINUE READING